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De-Stressing the Brain


  • A reduction in stress-related brain activity may be behind some of exercise’s heart health benefits

  • People with higher levels of physical activity had lower stress-related activity in the brain and a 23% lower risk of developing cardiovascular disease compared to those who didn’t exercise regularly

  • Stress signals in the brain are linked to inflammation, hardening or thickening of the arteries, increased blood pressure and higher sympathetic nervous system activity

  • Exercise was about twice as effective in lowering cardiovascular disease risk among people with depression

  • If you’re middle-aged or beyond, focus on fun, social and moderate-intensity exercise; too much vigorous exercise can backfire

By JM MD


Sources and References:

J Am Coll Cardiol. 2024 Apr 23;83(16):1543-1553. doi: 10.1016/j.jacc.2024.02.029

Massachusetts General Hospital April 16, 2024

CNN April 15, 2024

Missouri Medicine March-April 2023; 120(2): 155–162

Circulation August 16, 2022;146(7):523–534

Youtube November 22, 2023

Mayo Clinic Proceedings December 2018, Volume 93, Issue 12, P1775-1785

JAMA Netw Open. 2023 Mar; 6(3): e235174

Br J Sports Med. 2015 Jun;49(11):710-5. doi: 10.1136/bjsports-2014-094157. Epub 2015 Jan 19

GeroScience. 2023 Dec; 45(6): 3211–3239


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